In Kireedam with Ajith Kumar, Trisha tried comedy and received rave reviews.
Kireedam opened with high expectations and received good reviews from media and was declared a success.
She played a soft-spoken college-going Brahmin girl and received positive feedbacks for her performance, with Sify's reviewer citing that she was "appealingly sensual" and looked "glamorous", In 2004, she débuted in Telugu cinema with M S Raju's romance-action film Varsham, which turned her into an overnight sensation.
Critics lauded her performance as Sailaja, a middle-class girl who becomes a film star on her father's insistence; Jeevi from Idlebrain claimed that she was "beautiful" and a "big plus to the film", labelling her performance as "natural", A critic from praised her, citing that she had shown why Tamil Nadu was "busy building her a temple", further adding that she looked "so fresh and fine, you feel like gifting her to the roses".
Her next release was Aadavari Matalaku Ardhalu Verule where she was cast opposite Venkatesh.
She was part of two male-oriented action-masala flicks Thirupaachi and Aaru, directed by Perarasu and Hari, which both offered only limited roles for her, In her second Telugu project, the sentimental drama Nuvvostanante Nenoddantana, she starred alongside Siddharth.
The film, being Prabhu Deva's directorial début, opened to rave reviews, with Trisha receiving unanimous praise for her portrayal as the village girl Siri, which earned her three Best Actress prizes, including her second consecutive Filmfare Award and her first Nandi Award. Her tender looks, innocent face and Telugu traditional costumes make her a treat to watch", further labelling her expressions and "naughty antics" as excellent, Trisha later went on to reprise the role in its Tamil remake as well.
She also appeared in Falguni Pathak's music video Meri Chunar Udd Udd Jaye as Ayesha Takia's friend, which was directed by Radhika Rao and Vinay Sapru.
She was later approached for an acting role in Tamil movie Lesa Lesa by Indian film director Priyadarshan, which marked the beginning of her professional career as an actress.